ARCHIVES
VOL. 8, ISSUE 1 (2026)
Comparative neuroprotective effects of Vitamin E and Melatonin in Alzheimer’s Disease: Evidence from a clinical meta-analysis
Authors
Sandeep Goyal, Rakesh Chawla, Vijender Kumar, Ankit Arora
Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder that is
characterized by a gradual deterioration in cognitive abilities, the death of
neurons, and the formation of amyloid-β plaques with disease progression.
Oxidative stress is a significant contributor to the progression of Alzheimer's
disease (AD), which is a form of dementia. Melatonin and vitamin E are two
examples of antioxidant chemicals that have been the subject of research in
order to investigate the possible neuroprotective effects of these molecules.
The purpose of this research is to evaluate the effectiveness of vitamin E and
melatonin in the prevention and treatment of Alzheimer's disease. In order to
accomplish this goal, it makes use of a meta-analysis and a systematic review
of randomized controlled trials. Through the use of electronic databases such
as PubMed, Scopus, MEDLINE, and the Cochrane Library, relevant studies that
were published between the years 2000 and 2022 were located and found when
doing the search. For the purpose of the meta-analysis, a total of eight
randomized controlled trials that were suitable for inclusion were included.
Melatonin and vitamin E were found to have significant neuroprotective benefits
when compared to a placebo, according to a pooled analysis. A comparison of the
therapeutic efficacy of monotherapy with that of the combination of vitamin E
and melatonin revealed that the combination was more effective. Based on the
findings, it appears that taking antioxidant supplements may have the potential
to slow down the progression of Alzheimer's disease and improve clinical
outcomes.
Download
Pages:52-57
How to cite this article:
Sandeep Goyal, Rakesh Chawla, Vijender Kumar, Ankit Arora "Comparative neuroprotective effects of Vitamin E and Melatonin in Alzheimer’s Disease: Evidence from a clinical meta-analysis". International Journal of Medical Science and Clinical Research, Vol 8, Issue 1, 2026, Pages 52-57
Download Author Certificate
Please enter the email address corresponding to this article submission to download your certificate.