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VOL. 7, ISSUE 2 (2025)
Multidrug resistance Pseudomonas aeruginosa and Staphylococcus aureus isolated from wound patients in Alex Ekwueme Federal University Teaching Hospital Abakaliki.
Authors
Chibuike Kingsley U, Iroha Ifeanyi R, Okeh Emmanuel O, Nwakaeze Emmanuel A, Ugah Uchenna I
Abstract
The inappropriate use of antimicrobials, along
with environmental conditions, leads to the emergence of multi-drug-resistant
bacteria. The present study determined the Multidrug-resistance Pseudomonas
aeruginosa and Staphylococcus aureus Isolated from Wound Patients in
Alex Ekwueme Federal University Teaching Hospital Abakaliki. A total number of
229 wound samples were collected from wound patients and analyzed using
standard microbiology techniques to determine the presence and distribution of Pseudomonas
aeruginosa and Staphylococcus aureus isolates.
Antibiotic susceptibility testing and multidrug resistance of these isolates
were performed using a modified Kirby-Bauer disk diffusion method. Out of the
229 wound samples analyzed, Gram positive and negative bacteria were isolated
in 132 (57.6 %) samples, out of which, Pseudomonas aeruginosa was 39.4 %
while 60.6 % was S. aureus. Analysis of antibiotic resistance rates
indicated that most of the S. aureus isolates were resistant to,
imipenem (95.0 %), oxacillin (85.0 %), cefotaxime (85.0 %), and erythromycin
(55.0 %), while the P. aeruginosa isolates showed resistance to cefepime
(86.5 %), trimethoprim/sulphamethaxazole (84.6 %), amoxicillin/clavulanic acid
(80.8 %), cefotaxime (80.8 %), ceftazidime (78.8 %) and ceftriaxone (73.1 %).
The multiple antibiotic resistance indexes showed an average of 0.70, which
indicated that isolated P. aeruginosa and S. aureus were
multi-drug-resistant. The identification of the most effective
antibiotics against some microbial species could orient the clinicians towards
the administration of some antimicrobials rather than others, resulting in a
limitation in the use of less effective drugs for the treatment of wound
infections.
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Pages:12-16
How to cite this article:
Chibuike Kingsley U, Iroha Ifeanyi R, Okeh Emmanuel O, Nwakaeze Emmanuel A, Ugah Uchenna I "Multidrug resistance <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i> isolated from wound patients in Alex Ekwueme Federal University Teaching Hospital Abakaliki.". International Journal of Medical Science and Clinical Research, Vol 7, Issue 2, 2025, Pages 12-16
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