The NCDs are now almost a pandemic for many populations worldwide. The double burden of disease has taken a new shape in which NCDs are now afflicting low- and middle-income countries, those primarily suffering from communicable or infectious diseases. The global burden of both non-communicable disorders and rare diseases represents a contemporary and future public health challenge in pediatrics. Growth and development at childhood practically affect one's future health and quality of life in adulthood. Childhood serves as a focal point for life-course approaches to the prevention, management, and treatment of NDCs, and rare diseases which represent a golden window of opportunity to improve and promote every patient’s right to health. According to the World Health Organization, they account for 86% of deaths and 77% of the disease burden in WHO European Regions. If nothing changes, NCDs are projected to account for 55 million deaths by 2030. Around 35% of deaths due to NCDs in the WHO regions arise from four main causes of premature mortality-CVDs, cancers, chronic respiratory diseases, and diabetes. While, however, the cause of reduced premature mortality may have different implications for chronic diseases, people tend to live longer but with chronic disabilities. Multimorbidity involved 65% of individuals over the age of 65 and called for much more patient-centered and complicated models of care.