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VOL. 6, ISSUE 2 (2024)
Use of Fosfomycin to prevent infection following ureterorenoscopy in case of shortage of cephalosporin: A retrospective study
Authors
Santosh Kumar Jha
Abstract
Antibiotic prophylaxis plays a critical role in preventing
post-operative infections following ureterorenoscopy (URS), with cephalosporins
commonly used for this purpose. However, periodic shortages of cephalosporins
present a challenge for healthcare providers, necessitating the search for
effective alternative antibiotics. This study investigates the efficacy of
fosfomycin as a prophylactic agent in URS procedures during cephalosporin
shortages. A retrospective analysis of 752 patients undergoing URS between
January 2018 and December 2020 was conducted, comparing those who received
cephalosporin (n=376) and those who received fosfomycin (n=376). The primary
outcome was the incidence of post-operative urinary tract infections (UTIs),
with secondary outcomes including hospital stay duration, readmission rates,
and antibiotic-related adverse events. Results showed no significant
differences in UTI rates (cephalosporin 3.7%, fosfomycin 4.3%, p=0.68),
hospital stay (p=0.82), or adverse events (p=0.37). Fosfomycin, therefore,
appears to be a safe and effective alternative to cephalosporins during
shortages, offering a viable option for maintaining patient care without
compromising outcomes.
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Pages:1-7
How to cite this article:
Santosh Kumar Jha "Use of Fosfomycin to prevent infection following ureterorenoscopy in case of shortage of cephalosporin: A retrospective study". International Journal of Medical Science and Clinical Research, Vol 6, Issue 2, 2024, Pages 1-7
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