COVID-19 is a new disease designated by WHO as a pandemic. COVID-19 is caused by a new variant of the coronavirus called SARS-CoV-2. Monocytes and eosinophils are part of the innate immune system that is not specific to a particular antigen. This study set monocyte levels 3-8% and eosinophil levels 2-4% as normal values. This study aims to determine the profile of monocytes and eosinophils in COVID-19-positive patients. The design of this study was cross-sectional, using 68 medical records of patients who underwent PCR and complete blood tests. The results showed that there were 21 patients with normal monocyte counts (30.8%), 24 patients with decreased eosinophil counts (35.2%), and 15 patients with normal monocyte counts and decreased eosinophil counts (27.3%). Conclution: this study indicates that the examination of the number of monocytes and eosinophils cannot be used as screening material for COVID-19.