Background: In the recent coronavirus pandemic it is anticipated that most fatalities are due to co-infection or superinfection followed by sepsis specially in ICU. Moreover irrational use of broad spectrum antibiotics skyrocketing the development of multidrug resistant organisms and further deteriorating the situation. Objectives: The objective of this study was to identify bloodstream pathogens and their antibiotic resistance pattern as it is crucial to implement antibiotic stewardship for better clinical outcome. Materials and methods: All blood cultures were collected from suspected septicaemic patients of COVID -19 admitted in ICU. A predesigned questionnaire was used to collect relevant data. Blood cultures were done using BD BACTEC FX (USA origin).The positive blood culture were inoculated on different media as standard protocol. Identification and antimicrobial susceptibility testing of isolates were done by Kirby-Bauer disc diffusion method and BD Phoenix M50 automated system. Results: Out of 1520 patients admitted in COVID ICU, 716 patients developed sepsis like syndrome and were subjected to blood culture. The blood culture positivity was 82/716(11.45%).All the five bacteria isolated from culture were gram negative. Burkholderia cepacia was the predominant one (45.12%). All the isolates were multidrug resistant (MDRO) and observed in 85% of cases. The rate of carbapenem resistance was seen in K.pneumoniae, E.coli, A.baumannii and Pseudomonas spp (70%,75%,100%,44.4% respectively) Burkholderia, Pseudomonas, Acinetobacter, klebsiella and E coli were found moderate to high level resistant to second, third and fourth generation cephalosporins. Overall colistin and tigecyclin were the two antibiotcs showed good sensitivity against all the bacteria isolated in this study except Burkholderia which was highly sensitive to pipercillin+ tazobactum and meropenam. Conclusion: Gram-negative bacteria were identified in COVID-19 associated sepsis and Burkholderia cepacia was cardinal among them. The presence of comorbidities, mechanical ventilation, contaminated disinfectants or nebulizer solutions, indwelling devices possibly contribute to BSIs. The prevalence of MDRO as causative agent of co-infection or superinfetion is alarming and warrants the pattern of their resistance for initiating empiric antibiotimicrobial therapy in septicaemic patients to decrease morbidity and mortality.