Background: The aim of this study is to comparative study of effect of adjuvant dexamethasone and dexmedetomidine with bupivacaine on Postoperative analgesia in Transverse abdominis plane block. Methods: A randomised prospective study was conducted in Sir Sunderlal hospital, Banaras Hindu University. The study included ASA I-II patients scheduled for lower abdominal surgeries. After induction of General Anaesthesia TAP block was given bilaterally with ultrasound guidance using a high frequency (5-10MHz) linear probe. In the Group AD 20 ml of 0.25% bupivacaine and 2 ml dexamethasone (8 mg) as adjuvant was given whereas, in Group BD 20 ml of bupivacaine 0.25% and dexmedetomidine 1.2 mcg/kg as adjuvant was administered. Visual analogue score (VAS) and patient satisfaction score were used to assess the quality of analgesia in immediately as well as at 2, 4, 8, 12 and 24 hours respectively in the postoperative period. Results were given as mean ± SD. Data collected were analysed using Student’s t-test. Differences were considered statistically significant if P values were <0.05. Results: Sixty patients were included in the study of which 30 patients each were randomly assigned to one of the 2 groups. Two Patients dropped out from the group AD. Patients who had dexmedetomidine as an adjunct in their TAP block had lesser variation in Heart Beat, MAP and lesser VAS score and higher Patient Satisfaction Score(p<0.05). Conclusion: We conclude that TAP block with 0.25% bupivacaine plain with dexmedetomidine 1.2 mcg/kg 20 ml on each side provides better postoperative analgesia and lesser VAS score which is better than TAP block with 0.25% bupivacaine plain with dexamethasone 8mg 20 ml on each side.