The objective is to evaluate the contribution of hepatitis B and C in the development of Hepatocellular Carcinoma (HCC) and to estimate the burden of HCC in patients with chronic liver disease. It is a prospective, cross-sectional study and the 109 patients are selected by consecutive sampling technique. The study is conducted at Medical Ward 2, Allied Hospital, Faisalabad, from November 2018 to May 2019. Out of 109 patients of Hepatitis induced Decompensated Chronic Liver Disease (DCLD), 64 are females, 45 are males, with female to male ratio of 1.44. Out of the total, 87 patients have developed liver cirrhosis and 22 have developed HCC in the background of liver cirrhosis. HCC develops most commonly within 6 to 10 years of chronic hepatitis. Among all these patients, 1 and 108 patients are seropositive for hepatitis B and C, respectively. Hepatitis C is more prevalent than hepatitis B in our setup, with the female preponderance. Progression of Hepatitis to DCLD and then to HCC is faster, more common within 6 to 10 years after hepatitis B or C infection.