Comparison of efficacy of oral clonidine and intravenous fentanyl in attenuation of hemodynamic stress response to laryngoscopy and tracheal intubation
Smitha A, Mahabala T H
Background: Direct laryngoscopy and tracheal intubation after induction of anesthesia are nearly always associated with sympathetic hyperactivity. To attenuate the pressor response, various drugs have been tried, but very few studies have been done to assess the effect of oral clonidine and IV fentanyl on the hemodynamic response during laryngoscopy and tracheal intubation.Aims and objectives: This study was conducted to assess and to compare the effect of oral clonidine and intravenous fentanyl for the attenuation of the pressor response during direct laryngoscopy and intubation.Materials and methods: Prospective, randomised, double blind, comparative study conducted at KVG Medical college and hospital, Sullia on 60 patients randomly allocated into two groups of 30 each. The patients in group C were given 150mcg of tab clonidine and group F were given inj. fentanyl 2mcg/kg respectively. Cardiovascular parameters (heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure,) were recorded at the following intervals: Baseline, pre-induction, after induction, at endotracheal intubation, one minute, three minutes and five minutes after intubation.Stastistical analysis: Analysed by mean, standard deviation and analysis of variance and chi square test. P value of <0.05 was cosidered significant.Results: The hemodynamic variables in clonidine group significantly lower than fentanyl group for first five minutes after laryngoscopy and intubation.Conclusion: Both clonidine and fentanyl were able to attenuate the hemodynamic response to laryngoscopy and intubation, however, Tab clonidine 150mcg given 90 minutes prior to intubation kept the hemodynamic variables significantly lower than those seen in fentanyl 2 mcg/kg I.V given 5 min prior to intubation.
Smitha A, Mahabala T H. Comparison of efficacy of oral clonidine and intravenous fentanyl in attenuation of hemodynamic stress response to laryngoscopy and tracheal intubation. International Journal of Medical Science and Clinical Research, Volume 3, Issue 4, 2021, Pages 36-41