Objective: To study the occurrence of metabolic and hematologic abnormalities in infant of diabetic mothers and to know the occurrence of congenital anomalies in infant of diabetic mothers. Design: Hospital based prospective studySetting: tertiary care hospital Participants: Neonates of mothers diagnosed to have gestational diabetes mellitus or overt diabetes mellitus admitted in K.V.G. Medical College, Sullia. During the period 1st December 2019 to 30th November 2020.Results: The present study is a hospital based prospective study to know the occurrence of metabolic, hematological abnormalities, congenital anomalies in infant of diabetic Mother. Among the 86 neonates born to diabetic mothers (GDM + overt DM), 44 (51.8%) were found to have hypoglycemia whereas 36 (42%) had hypocalcemia. 38 of the 86 (44%) were found to have polycythemia whereas 36 (42%) were found to have hyperbilirubinemia. 9 (11%) had cardiovascular anomalies, each one case of (1.8%) CNS and renal anomaliesConclusions: The following conclusions can be drawn from this study. Among the pregnancies complicated by diabetes, GDM continues to have a major contribution. Hypoglycemia remains the most common biochemical abnormality followed by, polycythemia and hyperbilirubinemia, statistically significant in infants of GDM mothers. Congenital heart diseases were the most common among congenital anomalies, VSD being the commonest.