Adjuvant effects of intrathecal dexmeditomedine with low dose bupivacaine versus a higher dose of bupivacaine in patients undergoing trans urethral resection of prostate surgery
Rakesh Kalappa, Varsha Kothari, Anupama Gupta
The patients undergoing TURP surgeries are elderly who have many comorbities involving multiple organs. It is beneficial if the block height is limited to T10 sensory level which is sufficient for TURP surgeries. The aim of the study was to compare the adjuvant effects of dexemedetomidine with low dose bupivacaine in patients undergoing TURP surgeriesMethods: Thisprospective, double-blinded, randomised study included sixty patients of ASAGrade I–III scheduled for TURP. They were randomised into two group using computer generated random number table. Group A received 7.5 mg of hyperbaric bupivacaine and Group B received dexmedetomidine (3mg) with low dose bupivacaine(6mg). Outcome variables included time of onset of block, duration of sensory and motor block and, requirement of rescue analgesics.. Results: Baseline and demographic data were comparable among the groups. The time to reach T10 was faster (10.98±1.38 min) in group B than group A (12.49±1.21 min), P = <0.001), longer duration of motor block (133.32±6.6 vs. 118.38±6.47min, P< 0.001) and increased time to first analgesic requirement. (302.37±9.94vs.221.57±7.30min,P<0.0001) were observed in group B Conclusion: Intrathecal dexmedetomidine with low-dose bupivacaine provides faster onset, prolonged sensory and motor block and reduced rescue analgesic requirement in patients undergoing TURP.